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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7060 | Amantadine | 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine | Others |
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. | |||
T9945 | MNK8 | 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione | STAT |
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1]. | |||
T1406 | Amantadine hydrochloride | 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride | Dopamine Receptor , Influenza Virus |
Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease. | |||
T13741 | Isoviolanthin | Others | |
Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat... | |||
T5A2455 | Arenobufagin | Others | |
Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells. | |||
T60420 | Anticancer agent 73 | DNA/RNA Synthesis | |
Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metasta... | |||
T2789 | Scutellarin | Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide | Akt , HIV Protease , STAT |
Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signal... | |||
T60604 | XST-14 | Apoptosis , Autophagy | |
XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells... | |||
T4A2399 | Cinobufotalin | IL Receptor , Akt , MRP , P-gp | |
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent... | |||
T64529 | MDL-800 | MDL 800,MDL800 | Sirtuin |
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer. | |||
T3391 | Corosolic acid | Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid | FAK , Autophagy |
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci... | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T3403 | Glabridin | Q-100692,KB-289522,LS-176045 | Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR |
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on... | |||
T3226 | Paritaprevir | ABT-450,Veruprevir | HCV Protease |
Paritaprevir (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity again... | |||
T15234 | ENMD-1198 | IRC 110160,ENMD-119,ENMD 1198 | HIF , STAT |
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells. | |||
T68875 | Xylocydine | ||
Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as... | |||
T70988 | Ibulocydine | ||
Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomo... | |||
T64085 | KRAS G12C inhibitor 43 | ||
KRAS G12C inhibitor 43 is a potent inhibitor of KRAS G12C and inhibits the migration and proliferation of H358 cells (IC50: 0.001-1 μM μM), A549 cells (IC50>1 μM) and HCC cells (IC50>1 μM). | |||
T38977 | Autophagy-IN-C1 | Autophagy-IN-C1 | |
Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea. Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells. | |||
T79341 | Tubulin polymerization-IN-45 | ||
Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site. It induces apoptotic cell death in hepatocellular cancer (HCC) cells [1]. |